The Future of
Autonomic Testing
Is Here.
Physio PS is the world's most advanced Autonomic Nervous System diagnostic platform — built by the doctors who wrote the books, powered by AI that connects the dots mainstream medicine misses.
The Only P&S Test
On the Market
Most autonomic monitoring only measures the sympathetic nervous system or heart rate variability. Physio PS monitors both Parasympathetic and Sympathetic branches — independently, simultaneously, and quantitatively — using algorithmic measurement of LFa and RFa.
Independent P&S Monitoring
Simultaneously and independently quantify Parasympathetic (RFa) and Sympathetic (LFa) activity. No other technology on the market achieves this dual-branch precision — validated by Colombo et al., Clinical Autonomic Dysfunction, Springer 2014.
15-Minute Test
Simple, non-invasive monitoring session that reveals what standard tests miss. No needles, no radiation, no risk.
FDA 510(k) Cleared
Regulatory-cleared medical device backed by peer-reviewed clinical research and validated diagnostic algorithms.
Portable & Deployable
Battery-powered, compact design. Perfect for clinics, in-home care, sports medicine, field deployment, and mobile diagnostics.
Revenue Generator
Supported by fundable billing codes. Multiple purchase options. Transform your practice with a new revenue stream while improving patient outcomes.
50+ Conditions.
One Platform.
PhysioPS ANS testing provides physicians with actionable data across an unprecedented spectrum of diseases and disorders — many of which go undetected by standard diagnostic methods.
Your Body Is Talking.
Are You Listening?
The Autonomic Nervous System controls every involuntary function — heart rate, digestion, breathing, blood pressure, immune response. When it breaks down, your entire body sends distress signals. Hover over each system to see what standard medicine misses.
Select an Organ System
Click or hover on any glowing organ to see how autonomic dysfunction affects it — and what standard medicine misses.
See Your Nervous System
In Real-Time
This is what a 15-minute PhysioPS ANS test reveals — the invisible data that standard diagnostics completely miss.
Two Paths.
One Decision.
Every patient reaches a fork in the road. The path you choose determines everything — your health, your wallet, your life.
15-minute ANS test reveals autonomic dysfunction early.
Doctor says "let's wait and see" — orders basic blood panel.
Root cause identified. Targeted treatment begins. No unnecessary medications.
Symptoms worsen. Referred to specialist #1. Prescribed first medication.
Autonomic function restored. Patient thriving.
Total cost: ~$2,000
Now on 4 medications. Specialist #3. Side effects creating new symptoms.
Total cost: ~$45,000
Proactive monitoring catches new issues early. Full quality of life.
Chronic disease management. Monthly pharma prescriptions. Quality of life declining.
Total cost: ~$180,000
Healthy, proactive, empowered. ANS testing saved their life — like Steve O'Leary's widow maker.
Hospitalized. Emergency intervention. "If only we'd caught this earlier..."
Total cost: ~$500,000+
The Uncomfortable
Truth
Big Pharma spends more on MARKETING than R&D
2/3 of new drugs are "me-too" copies — no therapeutic breakthrough
Spent annually treating symptoms of diseases that could be CURED
Americans with undiagnosed autonomic dysfunction
Average number of doctors before getting a correct autonomic diagnosis
There is another way. PhysioPS doesn't mask your symptoms.
It finds why you're sick.
ANS Diagnostic
Engine
Our AI-powered HumanOS platform transforms raw .ans file data into comprehensive clinical reports in seconds. Powered by Dr. Colombo's P&S methodology, the engine performs spectral HRV analysis, AI pattern recognition, and real-time diagnostic interpretation.
P&S Spectral Analysis
Frequency-domain decomposition isolating sympathetic (LFa) and parasympathetic (RFa) tones across baseline, deep breathing, Valsalva, and standing challenges.
AI Pattern Recognition
Automated detection of Autonomic Dysfunction, Sympathetic Excess, Parasympathetic Excess, and cardiovascular autonomic neuropathy staging.
Instant Report Generation
Upload a .ans file, receive a clinician-ready 10-slide diagnostic presentation with therapy recommendations in under 30 seconds.
Drop .ans file here or click to upload
From .ans file to
clinical report — in 30 seconds.
HumanOS ingests raw ANS waveforms and returns a clinician-ready, 10-slide diagnostic report — complete with P&S spectral analysis, autonomic state classification, and therapy recommendations grounded in Dr. Colombo's methodology.
Spectral P&S Decomposition
LFa / RFa isolation across baseline, deep breathing, Valsalva, and standing — the only dual-branch quantification on the market.
12-Class ANS State Classifier
NVIDIA Blackwell inference at 7.8 ms with 98.7% accuracy across Sympathetic Excess, Parasympathetic Excess, DAN, CAN staging, and 8 more states.
Evidence-First Reporting
Every flag is traceable to a frequency-domain feature and a peer-reviewed citation. No black boxes. No hand-waving.
A Live Window into the
Autonomic Nervous System
Every PhysioPS session streams multi-modal biometrics — PPG, ECG, GSR, RESP, TEMP — into the HumanOS classifier running on Akamai edge GPUs. What you see below is the actual telemetry layer clinicians use during a 15-minute test.
Dual-Branch Spectral Analysis
Live LFa / RFa / HRV band ratios — sympathetic vs. parasympathetic resolved independently and simultaneously.
Early-Stage CAN Indicator
A Single 30-Minute Session.
Three Diagnostic Windows.
PhysioPS sessions follow a structured three-phase protocol — every challenge isolates a different autonomic dimension. The HumanOS engine fuses the windows into a single, longitudinal autonomic fingerprint.
Establishes the patient's resting autonomic tone. We capture supine HRV, sympathovagal balance, and baseline coherence — the reference frame for every downstream signal.
Controlled Valsalva and standing challenges quantify the sympathetic response curve. We measure response latency, amplitude, and recovery slope — the markers standard tilt-tables miss.
Deep-breathing protocols isolate the vagal recovery vector — a powerful early indicator of CAN, dysautonomia, and recovery resilience after PTSD, concussion, and long-COVID.
A Diagnostic Cloud
Closer Than the Hospital Down the Street.
HumanOS inference rides Akamai's distributed edge — 4,200+ points of presence, sub-10 ms response in every major medical metro, isolated NVIDIA Blackwell GPU pools for diagnostic-grade compute.
AI That Connects
The Dots
Mainstream medicine treats symptoms. We find root causes. Our AI diagnostic engine aggregates and interprets data from ANS tests, epigenetics, methylation panels, trace minerals, hormones, and blood work — connecting patterns that are impossible for a single doctor to see.
The Diagnostic Gap
Doctors aren't trained to interpret the sheer volume of data from methylation panels, micronutrient tests, and trace mineral analyses. These tests fall outside standard protocols — so they're never ordered, and root causes stay hidden.
Our AI Solution
Our engine processes ANS data, epigenetics, methylation panels, trace minerals, hormones, and blood work simultaneously — automating the complex task of connecting disparate data points into actionable clinical intelligence.
Cellular Mechanism
Deficiencies in vitamins and minerals, combined with toxin accumulation from microplastics, burn pits, and environmental exposure, directly compromise the ANS — sending the body down a path of chronic illness that traditional medicine can't reverse.
Treatment Protocol
Holistic cellular repair through targeted supplementation, proper hydration, and chelation of toxins using natural compounds like fulvic and humic acid — proven protocols that circumvent the pharmaceutical route entirely.
Beyond the Brain:
The ANS Connection
A landmark 2026 study published in Brain Medicine — co-authored by Dr. Joseph Colombo, the pioneer behind Physio PS technology — enrolled more than 8,000 patients and proved that autonomic dysfunction may be the root cause of treatment-resistant depression.
"What we found, again and again, was that these patients were not treatment resistant in any meaningful sense..."
— Dr. Joseph Colombo, Neurologist, Franklin Cardiovascular Associates
"For too long, psychiatry has accepted the label of treatment-resistant depression as a verdict rather than a challenge."
— Dr. Michele Pato, Psychiatrist, Rutgers University
Brain Medicine (2026)
Is it really treatment-resistant depression? Parasympathetic and sympathetic dysfunction as a treatment avenue.
Read the StudyKey Findings
- Autonomic dysfunction — not just brain chemistry — underlies many cases of treatment-resistant depression
- Traditional cardiac-only ANS measurement misses critical signals
- Comprehensive P&S testing revealed preclinical orthostatic dysfunction in most depression patients
- All patients improved after autonomic dysfunction treatment, regardless of specific therapy
Akamai Edge Compute
Lowest Latency. Fastest Results.
PhysioPS leverages Akamai's global cloud and edge compute infrastructure — delivering near-zero latency AI inferencing, dedicated NVIDIA Blackwell GPU instances, and post-quantum cryptography for the most sensitive medical data on Earth.
Near-Zero Latency
Edge nodes positioned globally ensure real-time diagnostic processing regardless of clinic location.
Dedicated GPU Instances
Private NVIDIA Blackwell GPU compute — isolated, high-performance AI inference with full data sovereignty.
Post-Quantum Security
Akamai post-quantum cryptography ensures patient data remains protected against future computational threats.
Global Scale
From remote clinics to major hospitals — Akamai's 4,200+ edge locations deliver consistent, enterprise-grade performance everywhere.
Wearable Sensory
Technology
The future of ANS testing is on your wrist. PhysioPS is building the next generation of wearable biosensors that continuously monitor autonomic function — bringing proactive healthcare from the clinic to everyday life.
- Continuous autonomic monitoring via wrist-based PPG and EDA sensors
- Real-time sympathovagal balance tracking throughout the day
- AI-driven anomaly detection with instant physician alerts
- Seamless integration with HumanOS diagnostic engine
- Edge-processed data for privacy-first architecture
A Skeptic's
Awakening
Steve O'Leary walked into his first ANS test as a skeptic. He walked out a believer — because the test told him something no other diagnostic could: he had a widow maker.
Sure enough, it was confirmed. A blockage so severe it's called the widow maker — the kind that ends lives without warning. The ANS test caught what years of standard checkups missed.
That moment changed everything. Steve didn't just become a patient success story — he became a man on a mission. As President and COO of Physio PS Inc., he's dedicated his life to bringing this technology to the masses of humanity.
"The healthcare world is reactive. You wait until something breaks, then you try to fix it. PhysioPS ANS testing flips that paradigm entirely — it's the most proactive diagnostic tool on the planet. If it saved my life, imagine what it can do for the 90 million Americans walking around with undiagnosed autonomic dysfunction."
Steve O'Leary CBP
President & COO, Physio PS Inc.
Slainte
Steve takes his first ANS test — skeptical, expecting nothing.
The test reveals a critical cardiac finding: a widow maker blockage.
Follow-up diagnostics confirm the ANS test results — his life is saved.
Steve joins Physio PS as President & COO. The mission: bring proactive ANS testing to the masses.
AI-powered diagnostics, wearable sensors, edge compute — building the new healthcare paradigm.
For Our
Veterans
Veterans exposed to burn pits in Afghanistan and Iraq carry toxic burdens that mainstream medicine can't diagnose with standard tools. PhysioPS ANS testing gives the VA the diagnostic intelligence to finally treat — not just manage — these warriors' invisible wounds.
Select a Target Market
The New Healthcare
Paradigm
PhysioPS sits at the center of an intelligent biopsychosocial ecosystem — combining ANS testing, regenerative medicine, AI diagnostics, and agentic AI companions to deliver proactive, personalized, and holistic care.
PhysioPS
ANS Testing
The Diagnostic CoreAntimatterAI
ATOM Agentic AI
antimatterai.comClinixAI
Digital Care Orchestration
tryclinixai.comRRG Bio
Stem Cell Therapies
rrg.bioThingk Tangk
HumanOS Platform
thingktangk.comBreaking
Ground
Looking Beyond the Brain to Alleviate Depression Symptoms
More than 330 million people worldwide have depression. New research shows autonomic dysfunction — not just brain chemistry — may be the root cause of treatment-resistant cases.
April 2026P&S Dysfunction as a Treatment Avenue for Depression
Landmark study by Pato, Colombo et al. with 8,000+ patients demonstrates comprehensive ANS testing reveals hidden autonomic causes of depression.
2026Clinical Autonomic Dysfunction: Measurement, Indications, Therapies
The definitive textbook by Colombo, Arora, DePace, and Vinik — the foundational science behind PhysioPS P&S methodology.
ReferenceWhat Doctors
Are Saying
Proactive Healthcare
Starts Now
Join the revolution. See how PhysioPS ANS testing can transform your practice, improve patient outcomes, and open new revenue streams.
Steve O'Leary CBP · President & COO